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Zestoretic 20 Mg Tablet 28's Walmark Special Offers Comfortable Seat: Padded for comfortableLisinopril works by blocking a substance in the body that causes the blood vessels to tighten. As a result, lisinopril relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart. Lisinopril is also used to help treat heart failure. Hydrochlorothiazide is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.