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Appropriate Dose Selection - How to Optimize Clinical Drug Development formatIsbn:Hardcover - 9783540278672 Immunoassays have been shown toOptimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e. g., due to concurrent illnesses or co medications. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. The continued use of biomarkers based on the (known) pharmacology of the drug and or biology of the underlying disease along